Intestinal anti-inflammatory activity of xique–xique (<i>Pilosocereus gounellei</i>A. Weber ex K. Schum. Bly. Ex Rowl) juice on acetic acid-induced colitis in rats

Abstract

had a protective effect on intestinal inflammation, with an improvement in macroscopic damage, and a decrease in pro-inflammatory markers and oxidative stress, in addition to preserving the colonic tissue. Immunohistochemical analysis revealed the downregulation of IL-17, NF-κB, and iNOS, and upregulation of SOCs-1, ZO-1, and MUC-2. These protective effects could be attributed to the phenolic compounds as well as the fibers present in xique-xique juice. Further studies are needed before suggesting the use of xique-xique juice as a new alternative for treating IBD.