Fexofenadine inhibits TNF signaling through targeting to cytosolic phospholipase A2 and is therapeutic against inflammatory arthritis

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Daniel Martinez Molina, Rozbeh Jafari, Marina Ignatushchenko et al. · Science · 2013 · 2.2K citations

Medicine, Oncology, Pharmacology +17

cPLA2 is phosphorylated and activated by MAP kinase

Lih‐Ling Lin, Markus Wartmann, Alice Lin et al. · Cell · 1993 · 1.9K citations

Life Sciences, Biochemistry, Molecular Biology +8

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

James D. Clark, Lih‐Ling Lin, Ronald Kriz et al. · Cell · 1991 · 1.7K citations

Life Sciences, Biochemistry, Cell Biology +6

The cellular thermal shift assay for evaluating drug target interactions in cells

Rozbeh Jafari, Helena Almqvist, Hanna Axelsson et al. · Nature Protocols · 2014 · 1.5K citations

Medicine, Cell Biology, Pharmacology +13

Collagen-induced arthritis

David Brand, Kary A. Latham, Edward F. Rosloniec · Nature Protocols · 2007 · 1.4K citations