James D. Clark

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

James D. Clark, Lih‐Ling Lin, Ronald Kriz et al. · Cell · 1991 · 1.7K citations

Signal Transduction, Molecular Physiology, Biochemistry +5

Purification of a 110-kilodalton cytosolic phospholipase A2 from the human monocytic cell line U937.

James D. Clark, N Milona, John L. Knopf · Proceedings of the National Academy of Sciences · 1990 · 429 citations

U937 Cells, Signal Transduction, Biochemistry +14

The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis.

Jennifer Hodge, Thomas T. Kawabata, Sriram Krishnaswami et al. · PubMed · 2016 · 371 citations

Immunology, Biological Therapy, Inflammation +16

Crystal Structure of Human Cytosolic Phospholipase A2 Reveals a Novel Topology and Catalytic Mechanism

Andréa Dessen, Jin Tang, Mark Stahl et al. · Cell · 1999 · 365 citations · Full text

Crystal Structure, Proteinlipid Interaction, Protein Function +9

Delineation of two functionally distinct domains of cytosolic phospholipase A2, a regulatory Ca(2+)-dependent lipid-binding domain and a Ca(2+)-independent catalytic domain.

Eric A. Nalefski, Lisa A. Sultzman, David Martin et al. · Journal of Biological Chemistry · 1994 · 352 citations · Full text