Concepedia

Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model

Kim Anthony-Gonda, Ariola Bardhi, Alex Ray, Nina C. Flerin, Mengyan Li, Weizao Chen, Christina Ochsenbauer, John C. Kappes, Winfried Krueger, Andrew Worden,

Science Translational Medicine · 2019 · 161 citations · 47 references

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Concepts

Abstract

T cells during HIV infection using a humanized NSG mouse model of intrasplenic HIV infection. These data suggest that multispecific anti-HIV duoCAR-T cells could be an effective approach for the treatment of patients with HIV-1 infection.

References

47

Antibody neutralization and escape by HIV-1

Xiping Wei, Julie M. Decker, Shuyi Wang et al. · Nature · 2003 · 2.4K citations

, , +12

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Adrienne H. Long, Waleed Haso, Jack F. Shern et al. · Nature Medicine · 2015 · 1.8K citations · Full text

, , +17

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

Terry J. Fry, Nirali N. Shah, Rimas J. Orentas et al. · Nature Medicine · 2017 · 1.3K citations

, , +14

SPICE: Exploration and analysis of post‐cytometric complex multivariate datasets

Mario Roederer, Joshua L. Nozzi, Martha Nason · Cytometry Part A · 2011 · 856 citations · Full text

, , +14

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117

Marina Caskey, Florian Klein, Julio C. C. Lorenzi et al. · Nature · 2015 · 774 citations

, , +12