Concepedia

Let-7f-5p suppresses Th17 differentiation via targeting STAT3 in multiple sclerosis

Zhihui Li, Yifei Wang, Dandan He, Xuemei Zhang, Yinglian Zhou, Hui Yue, Shan Huang, Zheng Fu, Lingyu Zhang, Zhuqing Mao,

Aging · 2019 · 44 citations · 33 references

DOIFull text

Open access

Concepts

Abstract

T cells from MS patients. In conclusion, let-7f-5p functions as a potential inhibitor of Th17 differentiation in the pathogenesis of MS by targeting STAT3 and may serve as a new therapeutic target.

References

33

Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria

Chris H. Polman, Stephen C. Reingold, Brenda Banwell et al. · Annals of Neurology · 2011 · 9.8K citations · Full text

, , +10

Global, regional, and national age–sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

The Lancet · 2014 · 7.5K citations · Full text

, , +17

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

Ivaylo I. Ivanov, Brent S. McKenzie, Liang Zhou et al. · Cell · 2006 · 5.1K citations · Full text

, , +16

New Multiple Sclerosis Phenotypic Classification

Fred Lublin · European Neurology · 2014 · 4.3K citations

, , +8

IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

Claire L. Langrish, Yi Chen, Wendy M. Blumenschein et al. · The Journal of Experimental Medicine · 2005 · 4K citations · Full text

, , +17