Concepedia

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Seo Rin Kim, Kai Jiang, Mikołaj Ogrodnik, Xiaojun Chen, Xiang-Yang Zhu, Hannah Lohmeier, Leena Ahmed, Hui Tang, Tamar Tchkonia, LaTonya J. Hickson,

Translational research · 2019 · 139 citations · 37 references

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References

37

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker, Bennett G. Childs, Matej Durik et al. · Nature · 2016 · 2.8K citations · Full text

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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.4K citations · Full text

, , +17

Senolytics improve physical function and increase lifespan in old age

Ming Xu, Tamar Pirtskhalava, Joshua N. Farr et al. · Nature Medicine · 2018 · 2.2K citations

, , +14

Cellular senescence drives age-dependent hepatic steatosis

Mikołaj Ogrodnik, Satomi Miwa, Tamar Tchkonia et al. · Nature Communications · 2017 · 1K citations · Full text

, , +17

p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype

Adam Freund, Christopher K. Patil, Judith Campisi · The EMBO Journal · 2011 · 1K citations · Full text

, , +13