Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: Novel classes of histone deacetylase inhibitors

The language of covalent histone modifications

Brian D. Strahl, C. David Allis · Nature · 2000 · 8.6K citations

Life Sciences, Biochemistry, Molecular Biology +12

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

Minoru Yoshida, Masako Kijima, Motomu Akita et al. · Journal of Biological Chemistry · 1990 · 1.9K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +17

Role of the histone deacetylase complex in acute promyelocytic leukaemia

Richard J. Lin, László Nagy, Satoshi Inoue et al. · Nature · 1998 · 1.1K citations

Life Sciences, Hematology, Molecular Biology +14

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked <i>in vivo</i> antitumor activity against human tumors

Akiko Saito, Takashi Yamashita, Yukiyasu Mariko et al. · Proceedings of the National Academy of Sciences · 1999 · 696 citations · Full text

Medicine, Oncology, Pharmacology +13

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

Stephen E. Rundlett, Andrew A. Carmen, Ryûji Kobayashi et al. · Proceedings of the National Academy of Sciences · 1996 · 629 citations · Full text

Life Sciences, Genetics, Molecular Biology +13