Concepedia

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ

Pedro A. Mateos‐Gómez, Tatiana Kent, Sarah Deng, Shane McDevitt, Ekaterina Kashkina, Trung Hoàng, Richard T. Pomerantz, Agnel Sfeir

Nature Structural & Molecular Biology · 2017 · 193 citations · 53 references

DOIFull text

Open access

Concepts

References

53

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

Raphaël Ceccaldi, Ravindra Amunugama, Ildikó Hajdú et al. · Nature · 2015 · 888 citations · Full text

, , +14

Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector

Elizabeth J. Robertson, Allan Bradley, Michael R. Kuehn et al. · Nature · 1986 · 756 citations

, , +14

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

Pedro A. Mateos‐Gómez, Fade Gong, Nidhi Nair et al. · Nature · 2015 · 751 citations · Full text

, , +9

Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining

Marc Audebert, Bernard Salles, Patrick Calsou · Journal of Biological Chemistry · 2004 · 683 citations · Full text

, , +17

Removal of Shelterin Reveals the Telomere End-Protection Problem

Agnel Sfeir, Titia de Lange · Science · 2012 · 584 citations

, , +17