Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

Raphaël Ceccaldi, Ravindra Amunugama, Ildikó Hajdú, +8

Nature

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

Raphaël Ceccaldi, Kalindi Parmar, Enguerran Mouly, +15

Cell stem cell

Progenitor CellsGenome InstabilityBone Marrow FailureCell DivisionMedicine +11

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

Beatrice Rondinelli, Ewa Gogola, Hatice Yücel, +8

Nature Cell Biology

ChromatinGenome InstabilityTranscriptional RegulationChromatin StructureChromatin Remodeling +10

A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors

Jia Zhou, Camille Gelot, Constantia Pantelidou, +11

Nature Cancer

Molecular BiologyCancer GeneticsMedicineHomologous-recombination-deficient TumorsNovel Therapy +1

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Zeina Kais, Beatrice Rondinelli, Amie L. Holmes, +4

Cell Reports

ChromatinGenome InstabilityCell RegulationMedicineNatural Sciences +12

Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions

Samuel Quentin, Wendy Cuccuini, Raphaël Ceccaldi, +20

Blood

A Unique Subset of Epithelial Ovarian Cancers with Platinum Sensitivity and PARP Inhibitor Resistance

Raphaël Ceccaldi, Kevin W. O’Connor, Kent W. Mouw, +4

Cancer Research

Parp InhibitorParp Inhibitor ResistanceGynecologyPathologyDna Repair Pathway +16

Biallelic inactivation of REV7 is associated with Fanconi anemia

Dominique Bluteau, Julien Masliah-Planchon, Connor S. Clairmont, +13

Journal of Clinical Investigation

Fa PhenotypeGeneticsPathologyBiallelic InactivationTranscriptional Regulation +15

CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress

Sara Przetocka, Antônio Porro, Hella Anna Bolck, +9

Molecular Cell

ChromatinGenome InstabilityMedicineGeneticsNatural Sciences +8

Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

Camille Gelot, Marton Tibor Kovacs, Simona Miron, +11

Nature