Raphaël Ceccaldi

Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

Raphaël Ceccaldi, Ravindra Amunugama, Ildikó Hajdú et al. · Nature · 2015 · 859 citations · Full text

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

Raphaël Ceccaldi, Kalindi Parmar, Enguerran Mouly et al. · Cell stem cell · 2012 · 339 citations · Full text

Progenitor Cells, Genome Instability, Bone Marrow Failure +13

EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation

Beatrice Rondinelli, Ewa Gogola, Hatice Yücel et al. · Nature Cell Biology · 2017 · 322 citations · Full text

Chromatin, Genome Instability, Transcriptional Regulation +12

A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors

Jia Zhou, Camille Gelot, Constantia Pantelidou et al. · Nature Cancer · 2021 · 320 citations · Full text

Molecular Biology, Cancer Genetics, Medicine +3

FANCD2 Maintains Fork Stability in BRCA1/2-Deficient Tumors and Promotes Alternative End-Joining DNA Repair

Zeina Kais, Beatrice Rondinelli, Amie L. Holmes et al. · Cell Reports · 2016 · 198 citations · Full text

Chromatin, Genome Instability, Cell Regulation +14