Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

Agnel Sfeir, Settapong T Kosiyatrakul, Dirk Hockemeyer, +4

Cell

ChromatinGenome InstabilityEfficient ReplicationNatural SciencesGenetics +9

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

Pedro A. Mateos‐Gómez, Fade Gong, Nidhi Nair, +3

Nature

Transcriptional RegulationMammalian Polymerase θNatural SciencesGeneticsDna Replication +3

53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection

Michal Zimmermann, Francisca Lottersberger, Sara B.C. Buonomo, +2

Science

ChromatinGenome InstabilityDna DamageEnd ResectionDouble-strand Break +12

Removal of Shelterin Reveals the Telomere End-Protection Problem

Agnel Sfeir, Titia de Lange

Science

End-protection ProblemChromatinGenome InstabilityMouse TelomeresNatural Sciences +11

POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end

Dirk Hockemeyer, Agnel Sfeir, Jerry W. Shay, +2

The EMBO Journal

ChromatinGenome InstabilityGeneticsHuman ChromosomesGenomic Mechanism +7

Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance

Marco Tigano, Danielle Vargas, Samuel Tremblay‐Belzile, +2

Nature

Genome InstabilityDna DamageMitochondrial FunctionNatural SciencesImmunology +7

Does a Sentinel or a Subset of Short Telomeres Determine Replicative Senescence?

Ying Zou, Agnel Sfeir, Sergei Gryaznov, +2

Molecular Biology of the Cell

Lifespan ExtensionChromatinGenome InstabilityTelomere ShorteningDevelopmental Biology +11

Loss of Rap1 Induces Telomere Recombination in the Absence of NHEJ or a DNA Damage Signal

Agnel Sfeir, Shaheen Kabir, Megan van Overbeek, +2

Science

ChromatinGenome InstabilityChromatin RemodelingMolecular RegulationNatural Sciences +12

Telomere Extension Occurs at Most Chromosome Ends and Is Uncoupled from Fill-In in Human Cancer Cells

Yong Zhao, Agnel Sfeir, Ying Zou, +4

Cell

ChromatinGenome InstabilityTelomere Extension OccursGeneticsDna Replication +7

Telomere-End Processing

Agnel Sfeir, Weihang Chai, Jerry W. Shay, +1

Molecular Cell