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C8-substituted pyrido[3,4-d]pyrimidin-4(3H)-ones: Studies towards the identification of potent, cell penetrant Jumonji C domain containing histone lysine demethylase 4 subfamily (KDM4) inhibitors, compound profiling in cell-based target engagement assays

Yann‐Vaï Le Bihan, Rachel M. Lanigan, Butrus Atrash, Mark McLaughlin, Srikannathasan Velupillai, Andrew G. Malcolm, Katherine S. England, G.F. Ruda, N. Yi Mok, Anthony Tumber,

European Journal of Medicinal Chemistry · 2019 · 17 citations · 47 references

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References

47

<i>Coot</i>: model-building tools for molecular graphics

Paul Emsley, Kevin Cowtan · Acta Crystallographica Section D Biological Crystallography · 2004 · 31K citations · Full text

<i>Phaser</i>crystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.6K citations · Full text

<i>XDS</i>

Wolfgang Kabsch · Acta Crystallographica Section D Biological Crystallography · 2010 · 16.5K citations · Full text

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<i>MolProbity</i>: all-atom structure validation for macromolecular crystallography

Vincent B. Chen, W.B. Arendall, Jeffrey J. Headd et al. · Acta Crystallographica Section D Biological Crystallography · 2009 · 14.4K citations · Full text

, , +16

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.8K citations

, , +8