Katherine S. England

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

Anthony Tumber, Andrea Nuzzi, Edward S. Hookway et al. · Cell chemical biology · 2017 · 141 citations · Full text

USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation

Emma V. Rusilowicz-Jones, Jane Jardine, Andreas Kallinos et al. · Life Science Alliance · 2020 · 124 citations · Full text

Mitophagy, Trigger Threshold, Molecular Biology +19

8-Substituted Pyrido[3,4-<i>d</i>]pyrimidin-4(3<i>H</i>)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors

Vassilios Bavetsias, Rachel M. Lanigan, G.F. Ruda et al. · Journal of Medicinal Chemistry · 2016 · 97 citations · Full text

Combinatorial Chemistry, Pharmaceutical Science, Drug Target +19

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin

Peter Jones, Richard Storer, Yogesh Sabnis et al. · Journal of Medicinal Chemistry · 2016 · 53 citations · Full text

Drug Target, Inflammatory Lung Disease, Lung Inflammation +21

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

Darragh P. O’Brien, Hannah B. L. Jones, Franziska Guenther et al. · Molecular & Cellular Proteomics · 2023 · 37 citations · Full text