FTY720 Inhibits MPP+-Induced Microglial Activation by Affecting NLRP3 Inflammasome Activation

A role for mitochondria in NLRP3 inflammasome activation

Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.4K citations

Life Sciences, Cell Biology, Molecular Biology +12

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Franz Bauernfeind, Gábor Horváth, Andrea Stutz et al. · The Journal of Immunology · 2009 · 2.9K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka, Markus P. Kummer, Andrea Stutz et al. · Nature · 2012 · 2.9K citations · Full text

Life Sciences, Neurology, Neuroscience +14

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +15

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

Ludwig Kappos, Ernst‐Wilhelm Radue, Paul O’Connor et al. · New England Journal of Medicine · 2010 · 2.6K citations · Full text

Life Sciences, Neurology, Pharmacotherapy +14