Concepedia

Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells

Maheshwor Timilshina, Zhiwei You, Sonja M. Lacher, Suman Acharya, Liyuan Jiang, Youra Kang, Jung‐Ae Kim, Hyeun Wook Chang, Keuk‐Jun Kim, Byoungduck Park,

Cell Reports · 2019 · 107 citations · 37 references

DOIFull text

Open access

Concepts

Abstract

cells, involved in optimal programming of suppressive activity, immune homeostasis, and tolerance.

References

37

Role of AMP-activated protein kinase in mechanism of metformin action

Gaochao Zhou, Robert P. Myers, Ying Li et al. · Journal of Clinical Investigation · 2001 · 5.4K citations

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mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Shih‐Chin Cheng, Jessica Quintin, Robert A. Cramer et al. · Science · 2014 · 2.1K citations

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Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

Ryan D. Michalek, Valerie A. Gerriets, Sarah R. Jacobs et al. · The Journal of Immunology · 2011 · 2K citations · Full text

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Reuben J. Shaw, Katja Lamia, Debbie S. Vasquez et al. · Science · 2005 · 1.9K citations

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HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Lewis Z. Shi, Ruoning Wang, Gonghua Huang et al. · The Journal of Experimental Medicine · 2011 · 1.8K citations · Full text

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