Concepedia

A novel bromodomain inhibitor, CPI-203, serves as an HIV-1 latency-reversing agent by activating positive transcription elongation factor b

Taizhen Liang, Xuanxuan Zhang, Fangyuan Lai, Jian Lin, Chenliang Zhou, Xinfeng Xu, Xing-hua Tan, Shuwen Liu, Lin Li

Biochemical Pharmacology · 2019 · 28 citations · 44 references

DOI

Concepts

References

44

Lead- and drug-like compounds: the rule-of-five revolution

Christopher A. Lipinski · Drug Discovery Today Technologies · 2004 · 6.1K citations

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Selective inhibition of BET bromodomains

P. Filippakopoulos, Jun Qi, S. Picaud et al. · Nature · 2010 · 4.3K citations · Full text

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CAESAR models for developmental toxicity

Antonio Cassano, Alberto Manganaro, Todd M. Martin et al. · Chemistry Central Journal · 2010 · 1.6K citations · Full text

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The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription

Moon Kyoo Jang, Kazuki Mochizuki, Meisheng Zhou et al. · Molecular Cell · 2005 · 1.3K citations · Full text

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Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4

Zhiyuan Yang, Jasper H. N. Yik, Ruichuan Chen et al. · Molecular Cell · 2005 · 1.1K citations · Full text

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