High-Throughput Fluorescence Polarization Assay to Identify Ligands Using Purified G Protein-Coupled Receptor

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Ji-Hu Zhang, Thomas D.Y. Chung, Kevin R. Oldenburg · SLAS DISCOVERY · 1999 · 7K citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +16

ZINC 15 – Ligand Discovery for Everyone

Teague Sterling, John J. Irwin · Journal of Chemical Information and Modeling · 2015 · 3.4K citations · Full text

Pharmacy, Bioinformatics, Medicinal Chemistry +13

Hypothermia and intolerance to cold induced by intracisternal administration of the hypothalamic peptide neurotensin

Garth Bissette, Charles B. Nemeroff, Peter T. Loosen et al. · Nature · 1976 · 314 citations

Life Sciences, Neuroscience, Pharmacology +14

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in <i>Escherichia coli</i>

Pascal Egloff, Matthias Hillenbrand, Christoph Klenk et al. · Proceedings of the National Academy of Sciences · 2014 · 208 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +15

Development of High Throughput Screening Assays Using Fluorescence Polarization: Nuclear Receptor-Ligand–Binding and Kinase /Phosphatase Assays

G.J. Parker, Tong Lin Law, Francis J. Lenoch et al. · SLAS DISCOVERY · 2000 · 207 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16