Philipp Heine

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

Hsin‐Yung Yen, Kin Kuan Hoi, Idlir Liko et al. · Nature · 2018 · 301 citations · Full text

Protein Chemistry, Protein Function, Signal Transduction +7

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution in<i>Escherichia coli</i>

Pascal Egloff, Matthias Hillenbrand, Christoph Klenk et al. · Proceedings of the National Academy of Sciences · 2014 · 207 citations · Full text

Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism

Mattia Deluigi, A. Klipp, Christoph Klenk et al. · Science Advances · 2021 · 62 citations · Full text

Molecular Biology, Ghrelin Family, Molecular Pharmacology +17

SPR-based fragment screening with neurotensin receptor 1 generates novel small molecule ligands

Sylwia Huber, Fabio Casagrande, Melanie N. Hug et al. · PLoS ONE · 2017 · 32 citations · Full text

Crystal Structure, Molecular Biology, Peptide Science +20

Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries

Anirudh Ranganathan, Philipp Heine, Axel Rudling et al. · ACS Chemical Biology · 2016 · 27 citations · Full text

Crystal Structure, Peptide Engineering, Molecular Biology +21