Melanie N. Hug

Synthetic single domain antibodies for the conformational trapping of membrane proteins

Iwan Zimmermann, Pascal Egloff, Cedric A. J. Hutter et al. · eLife · 2018 · 278 citations · Full text

Conformational Trapping, Protein Secretion, Proteinlipid Interaction +16

Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers

Manaswini Sivaramakrishnan, Kathleen McCarthy, Sébastien Campagne et al. · Nature Communications · 2017 · 219 citations · Full text

The subcellular arrangement of alpha-synuclein proteoforms in the Parkinson’s disease brain as revealed by multicolor STED microscopy

Tim E. Moors, Christina A. Maat, Daniel Niedieker et al. · Acta Neuropathologica · 2021 · 149 citations · Full text

DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome

Hans Richter, Alexander L. Satz, Marc Bedoucha et al. · ACS Chemical Biology · 2018 · 110 citations · Full text

Real-time monitoring of binding events on a thermostabilized human A2A receptor embedded in a lipid bilayer by surface plasmon resonance

Nicolas Bocquet, Josiane Kohler, Melanie N. Hug et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 2015 · 62 citations · Full text

Proteinlipid Interaction, Real-time Monitoring, Engineering +13