Concepedia

DNA-Encoded Library-Derived DDR1 Inhibitor Prevents Fibrosis and Renal Function Loss in a Genetic Mouse Model of Alport Syndrome

Hans Richter, Alexander L. Satz, Marc Bedoucha, Bernd Buettelmann, Ann Petersen, Anja Harmeier, Ricardo Hermosilla, Remo Hochstrasser, Dominique Burger, Bernard Gsell,

ACS Chemical Biology · 2018 · 113 citations · 31 references

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Abstract

mice also represent a model for chronic kidney disease, a disease which affects 10% of the global population.

References

31

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

Barry M. Brenner, Mark E. Cooper, Dick de Zeeuw et al. · New England Journal of Medicine · 2001 · 7.5K citations · Full text

, , +17

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

Dean G. Brown, Jonas Boström · Journal of Medicinal Chemistry · 2015 · 2K citations · Full text

, , +11

The Discoidin Domain Receptor Tyrosine Kinases Are Activated by Collagen

Wolfgang F. Vogel, Gerald Gish, Frauke Alves et al. · Molecular Cell · 1997 · 983 citations · Full text

, , +9

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

Ivica Grgic, Gabriela Campanholle, Vanesa Bijol et al. · Kidney International · 2012 · 472 citations · Full text

, , +10

Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome.

Jeffrey H. Miner, Joshua R. Sanes · The Journal of Cell Biology · 1996 · 323 citations · Full text

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