p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

Darren J. Baker, Bennett G. Childs, Matej Durik et al. · Nature · 2016 · 2.8K citations · Full text

Education, Cell Biology, Molecular Genetics +14

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Yi Zhu, Tamar Tchkonia, Tamar Pirtskhalava et al. · Aging Cell · 2015 · 2.4K citations · Full text

Life Sciences, Cell Biology, Pharmacology +17

Cellular senescence mediates fibrotic pulmonary disease

Marissa Schafer, Thomas A. White, Koji Iijima et al. · Nature Communications · 2017 · 1.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Ok Hee Jeon, Chaekyu Kim, Remi-Martin Laberge et al. · Nature Medicine · 2017 · 1.5K citations · Full text

Dentistry, Cell Biology, Orthopaedic Surgery +17

Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis

Norman E. Sharpless, Nabeel Bardeesy, Kee-Ho Lee et al. · Nature · 2001 · 850 citations

Medicine, Molecular Genetics, Oncology +12