Emanuel J. Novais

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

Emanuel J. Novais, Victoria A. Tran, Shira N. Johnston et al. · Nature Communications · 2021 · 427 citations · Full text

Education, Pharmacology, Pharmacotherapy +17

p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence

Emanuel J. Novais, Brian O. Diekman, Irving M. Shapiro et al. · Matrix Biology · 2019 · 103 citations · Full text

Life Sciences, Cell Biology, Molecular Genetics +14

Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model—An <scp>ORS</scp> spine section initiative

Itzel Paola Melgoza, Srish S. Chenna, Steven Tessier et al. · JOR Spine · 2021 · 82 citations · Full text

Medicine, Pathology, Biomedical Imaging +14

Lactate Efflux From Intervertebral Disc Cells Is Required for Maintenance of Spine Health

Elizabeth S. Silagi, Emanuel J. Novais, Sara Bisetto et al. · Journal of Bone and Mineral Research · 2019 · 73 citations · Full text

Life Sciences, Cell Biology, Physiology +17

TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression

Steven Tessier, Victoria A. Tran, Olivia K. Ottone et al. · Matrix Biology · 2019 · 66 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17