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Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy

Yuka Miyake, Yukihiro Itoh, Atsushi Hatanaka, Yoshinori Suzuma, Miki Suzuki, Hidehiko Kodama, Yoshinobu Arai, Takayoshi Suzuki

Bioorganic & Medicinal Chemistry · 2019 · 34 citations · 32 references

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32

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

Laurens Kruidenier, Chun‐wa Chung, Zhongjun Cheng et al. · Nature · 2012 · 958 citations · Full text

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The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3

Paul A. Cloos, Karl Agger, Alessio Maiolica et al. · Nature · 2006 · 749 citations

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Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

Shinya Hayami, John D. Kelly, Hyun‐Soo Cho et al. · International Journal of Cancer · 2010 · 481 citations · Full text

, , +16

Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

Soyoung Lim, Andreas Janzer, Astrid Becker et al. · Carcinogenesis · 2009 · 464 citations

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SnapShot: Histone Modifications

He Huang, Benjamin R. Sabari, Benjamin A. García et al. · Cell · 2014 · 425 citations · Full text