Concepedia

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

Daniel Shae, Kyle W. Becker, Plamen P. Christov, Dong Soo Yun, Abigail K. R. Lytton‐Jean, Sema Sevimli, Manuel Ascano, Mark C. Kelley, Douglas B. Johnson, Justin M. Balko,

Nature Nanotechnology · 2019 · 657 citations · 35 references

DOI

Concepts

References

35

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

Hiroki Ishikawa, Zhe Ma, Glen N. Barber · Nature · 2009 · 2.7K citations · Full text

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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

Liufu Deng, Hua Liang, Meng Xu et al. · Immunity · 2014 · 2.1K citations · Full text

, , +17

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

Seng‐Ryong Woo, Mercedes B. Fuertes, Leticia Corrales et al. · Immunity · 2014 · 1.8K citations · Full text

, , +12

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

Andrea Ablasser, Marion Goldeck, Taner Cavlar et al. · Nature · 2013 · 1.6K citations · Full text

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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

Leticia Corrales, Laura Hix Glickman, Sarah M. McWhirter et al. · Cell Reports · 2015 · 1.5K citations · Full text

, , +17