STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa et al. · Nature Immunology · 2004 · 3.8K citations

Essential Function, Viral Replication, Molecular Virology +10

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Hiroki Kato, Osamu Takeuchi, Shintaro Sato et al. · Nature · 2006 · 3.8K citations

Rig-i Helicases, Virus Structure, Viral Replication +11

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Hiroki Ishikawa, Glen N. Barber · Nature · 2008 · 3.4K citations · Full text

Inflammation, Host Response, Molecular Immunology +9

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

Rashu B. Seth, Lijun Sun, Chee-Kwee Ea et al. · Cell · 2005 · 3.2K citations · Full text

Signal Transduction, Mitochondrial Function, Mitochondrial Dynamic +6

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis et al. · Nature · 2009 · 2.5K citations · Full text

Signal Transduction, Natural Sciences, Cell Interaction +12