Concepedia

Design, synthesis and biological evaluation of novel indole derivatives as potential HDAC/BRD4 dual inhibitors and anti-leukemia agents

Gaoliang Cheng, Zhi Wang, Jinyu Yang, Yu Bao, Qihao Xu, Linxiang Zhao, Dan Liu

Bioorganic Chemistry · 2018 · 50 citations · 22 references

DOI

Concepts

References

22

Structure and ligand of a histone acetyltransferase bromodomain

Christophe Dhalluin, Justin E. Carlson, Lei Zeng et al. · Nature · 1999 · 1.7K citations

, , +12

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

S. Picaud, Christopher Wells, I. Felletar et al. · Proceedings of the National Academy of Sciences · 2013 · 481 citations · Full text

, , +11

Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways

Yi Jiang, Philippe Veschambre, Hediye Erdjument‐Bromage et al. · Proceedings of the National Academy of Sciences · 1998 · 304 citations

, , +17

Belinostat: First Global Approval

Raewyn Poole · Drugs · 2014 · 212 citations

, , +7

Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

David S. Hewings, O. Fedorov, P. Filippakopoulos et al. · Journal of Medicinal Chemistry · 2013 · 139 citations · Full text

, , +16