Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

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Inflammation, Cytokine, Inflammatory Disease +10

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

Hermann Schägger, Gebhard von Jagow · Analytical Biochemistry · 1991 · 2.2K citations

Proteinlipid Interaction, Biochemistry, Membrane Protein Complexes +11

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Evanna L. Mills, Beth Kelly, Angela Logan et al. · Cell · 2016 · 2.1K citations · Full text

Inflammation, Mitochondrial Function, Biochemistry +9

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Abhishek Jha, Stanley Ching‐Cheng Huang, Alexey Sergushichev et al. · Immunity · 2015 · 1.9K citations · Full text

Transcriptional Regulation, Systems Biology, Functional Genomics +15

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

Christiane A. Opitz, Ulrike Litzenburger, Felix Sahm et al. · Nature · 2011 · 1.8K citations · Full text

Tumor Biology, Oncogenic Agent, Medicine +8