The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease

Minghui Wang, Noam D. Beckmann, Panos Roussos, +26

Scientific Data

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

Insup Choi, Yuanxi Zhang, Steven P. Seegobin, +5

Nature Communications

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

Paras S. Minhas, Ling Liu, Peter K. Moon, +14

Nature Immunology

InflammationAutoimmune DiseaseInnate Immune SystemAutophagyImmunology +7

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

Alexandra Litvinchuk, Ying-Wooi Wan, Dan Swartzlander, +7

Neuron

Complement SystemAllergyMedicineImmunologyImmune Regulation +11

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Paras S. Minhas, Amira Latif‐Hernandez, Melanie R. McReynolds, +18

Nature

Alzheimer's DiseaseAgingLongevityDementiaMedicine +5

Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

Ryan Neff, Minghui Wang, Sezen Vatansever, +21

Science Advances

Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors

Dietmar Seiffert, Jodi D. Bradley, Cynthia M. Rominger, +18

Journal of Biological Chemistry

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology

Eddy W. Yue, Richard Sparks, Padmaja Polam, +23

ACS Medicinal Chemistry Letters

Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model

Eddy W. Yue, Brent Douty, Brian Wayland, +16

Journal of Medicinal Chemistry

PharmacotherapyVivo Pharmacodynamic ActivityPharmaceutical ChemistryTumor BiologyMedicinal Chemistry +15

Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

Minghui Wang, Aiqun Li, Michiko Sekiya, +39

Neuron

Neurodegenerative DiseasesSystems BiologyAlzheimer's DiseasePotential TherapeuticsOmics Integration +11