Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

Amit U. Joshi, Paras S. Minhas, Shane A. Liddelow, +4

Nature Neuroscience

InflammationNeurodegenerative DiseasesAlzheimer's DiseaseGliomaMedicine +10

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

Paras S. Minhas, Ling Liu, Peter K. Moon, +14

Nature Immunology

InflammationAutoimmune DiseaseInnate Immune SystemAutophagyImmunology +7

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Paras S. Minhas, Amira Latif‐Hernandez, Melanie R. McReynolds, +18

Nature

Alzheimer's DiseaseAgingLongevityDementiaMedicine +5

Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening

Grant L. Lin, Kelli M. Wilson, Michele Ceribelli, +30

Science Translational Medicine

Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy

Bereketeab Haileselassie, Amit U. Joshi, Paras S. Minhas, +3

Journal of Neuroinflammation

Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity

Qingkun Liu, Emily M. Johnson, Rachel Lam, +16

Nature Immunology

Intestinal ImmunogensImmunologyCerebral Vascular RegulationNeuroinflammationInflammation +15

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies

Paras S. Minhas, Jeffrey R. Jones, Amira Latif‐Hernandez, +30

Science

Tau OligomersAlzheimer ’Social SciencesGeriatric NeurologyAlzheimer's Disease +20

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Liang Zhang, Song Zhang, Izumi Maezawa, +17

EBioMedicine

The effects of passive and active learning on student preference and performance in an undergraduate basic science course

Paras S. Minhas, Arundhati Ghosh, Leah Swanzy

Anatomical Sciences Education

Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer’s disease model mice

Nathaniel S. Woodling, Damien Colas, Qian Wang, +17

Brain

Synaptic TransmissionNeurochemical BiomarkersSpatial Memory DeficitsAlzheimer ’Synaptic Signaling +19