Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

Amit U. Joshi, Paras S. Minhas, Shane A. Liddelow, +4

Nature Neuroscience

InflammationNeurodegenerative DiseasesAlzheimer's DiseaseGliomaMedicine +10

Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation

Paras S. Minhas, Ling Liu, Peter K. Moon, +14

Nature Immunology

InflammationAutoimmune DiseaseInnate Immune SystemAutophagyImmunology +7

Restoring metabolism of myeloid cells reverses cognitive decline in ageing

Paras S. Minhas, Amira Latif‐Hernandez, Melanie R. McReynolds, +18

Nature

Alzheimer's DiseaseAgingLongevityDementiaMedicine +5

VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease

Xing Guo, Xiaoyan Sun, Di Hu, +8

Nature Communications

Mitochondrial dysfunction mediated through dynamin-related protein 1 (Drp1) propagates impairment in blood brain barrier in septic encephalopathy

Bereketeab Haileselassie, Amit U. Joshi, Paras S. Minhas, +3

Journal of Neuroinflammation

Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy

Bereketeab Haileselassie, Riddhita Mukherjee, Amit U. Joshi, +7

Journal of Molecular and Cellular Cardiology

Heart FailureMolecular PhysiologyMitochondrial FunctionMitochondrial DysfunctionPhysiology +3

Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis

Amit U. Joshi, Nay L. Saw, Hannes Vogel, +3

EMBO Molecular Medicine

Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease

Amit U. Joshi, Nay L. Saw, Mehrdad Shamloo, +1

Oncotarget

Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes

Antje Ebert, Amit U. Joshi, Sandra Andorf, +8

Circulation Research

Novel and prevalent non-East Asian ALDH2 variants; Implications for global susceptibility to aldehydes’ toxicity

Che‐Hong Chen, Julio Cesar Batista Ferreira, Amit U. Joshi, +9

EBioMedicine