Curcumin alleviates DSS-induced colitis via inhibiting NLRP3 inflammsome activation and IL-1β production

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +15

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

Christian Bauer, Peter Duewell, Christine Mayer et al. · Gut · 2010 · 908 citations · Full text

Veterinary Medicine, Immunology, Pathology +17

IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4+ Th17 cells

Margherita Coccia, Oliver J. Harrison, Chris Schiering et al. · The Journal of Experimental Medicine · 2012 · 579 citations · Full text

Life Sciences, Immunology, Pathology +17

IL-1β Causes an Increase in Intestinal Epithelial Tight Junction Permeability

Rana Al–Sadi, Y. Thomas · The Journal of Immunology · 2007 · 577 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

Alexandra–Chloé Villani, Mathieu Lemire, Geneviève Fortin et al. · Nature Genetics · 2008 · 523 citations · Full text

Life Sciences, Immunology, Molecular Genetics +16