Concepedia

The LKB1–AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria

Javier Moral‐Sanz, Sophronia Lewis, Sandy MacMillan, Fiona A. Ross, Adrian Thomson, Benoı̂t Viollet, Marc Foretz, Carmel M. Moran, D. Grahame Hardie, A. Mark Evans

Science Signaling · 2018 · 39 citations · 50 references

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Abstract

channel in pulmonary arterial myocytes. We conclude that LKB1-AMPK-α1 signaling pathways downstream of mitochondria are critical for the induction of HPV, in a manner also supported by AMPK-α2 during severe hypoxia.

References

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