Concepedia

Alnylam launches era of RNAi drugs

Ken Garber

Nature Biotechnology · 2018 · 159 citations · 6 references

DOI

Concepts

References

6

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

David Adams, Alejandra González‐Duarte, William O’Riordan et al. · New England Journal of Medicine · 2018 · 2.9K citations · Full text

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Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

Merrill D. Benson, Márcia Waddington‐Cruz, John L. Berk et al. · New England Journal of Medicine · 2018 · 1.4K citations · Full text

, , +16

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

Maja M. Janas, Mark K. Schlegel, Carole E. Harbison et al. · Nature Communications · 2018 · 266 citations · Full text

, , +17

2′-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF

Wen Shen, Xue‐hai Liang, Hong Sun et al. · Nucleic Acids Research · 2015 · 104 citations · Full text

, , +16

Reversal of siRNA-mediated gene silencing in vivo

Ivan Zlatev, Adam Castoreno, Christopher R. Brown et al. · Nature Biotechnology · 2018 · 92 citations

, , +10