Adam Castoreno

Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning

Thouis R. Jones, Anne E. Carpenter, Michael R. Lamprecht et al. · Proceedings of the National Academy of Sciences · 2009 · 377 citations · Full text

Multiple Instance Learning, Engineering, Machine Learning +24

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

Maja M. Janas, Mark K. Schlegel, Carole E. Harbison et al. · Nature Communications · 2018 · 255 citations · Full text

Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection

Kara L. Conway, Petric Kuballa, Joo‐Hye Song et al. · Gastroenterology · 2013 · 229 citations

Inflammation, Cell Autophagy, Mitophagy +9

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates

Kirk Brown, Jayaprakash K. Nair, Maja M. Janas et al. · Nature Biotechnology · 2022 · 225 citations · Full text

Rnai Therapeutics, Liver Physiology, Gene Delivery +5

Reversal of siRNA-mediated gene silencing in vivo

Ivan Zlatev, Adam Castoreno, Christopher R. Brown et al. · Nature Biotechnology · 2018 · 92 citations

Genetics, Antisense Therapy, Small Rna +5