Significantly increased catalytic activity of<i>Candida antarctica</i>lipase B for the resolution of<i>cis</i>-(±)-dimethyl 1-acetylpiperidine-2,3-dicarboxylate

Abstract

Structure-based semi-rational engineering approach was applied to alter the binding pocket and substrate channel for enhancing the activity of CALB towards moxifloxacin chiral intermediate.