Concepedia

Binding Pocket Engineering

Binding Pocket Engineering is a methodological approach in protein design that involves the rational modification of the three-dimensional structure and physicochemical properties of a protein's substrate-binding site to alter its specificity or affinity toward target molecules.

124

Publications

5.5K

Citations

823

Authors

250

Institutions

Publications per year

2017–2026

57

Parents

Publications

124

De novo design of luciferases using deep learning

Hsien‐Wei Yeh, Christoffer Norn, Yakov Kipnis et al. · Nature · 2023 · 451 citations · Full text

, , +17

Molecular Interactions of CCR5 with Major Classes of Small-Molecule Anti-HIV CCR5 Antagonists

Rama K. Kondru, Jun Zhang, Changhua Ji et al. · Molecular Pharmacology · 2007 · 182 citations

, , +17

Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of alzheimer's amyloid β‐protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): Engineering of inhibitors with altered specificities

Axel J. Scheidig, Thomas R. Hynes, Laura A. Pelletier et al. · Protein Science · 1997 · 126 citations · Full text

, , +17

Can Machine Learning Revolutionize Directed Evolution of Selective Enzymes?

Guangyue Li, Yijie Dong, Manfred T. Reetz · Advanced Synthesis & Catalysis · 2019 · 125 citations · Full text

, , +16

Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice

Susanne Neumann, Wenwei Huang, Steve Titus et al. · Proceedings of the National Academy of Sciences · 2009 · 114 citations · Full text

, , +17

1–5 of 124

Authors

823

  1. ED
    Erik De Clercq

    Rega Institute for Medical Research, Belgium

    6 publications · 147 citations

    6

    h-index

  2. PZ
    Peng Zhan

    Shandong University, China

    5 publications · 133 citations

    5

    h-index

  3. XL
    Xinyong Liu

    Shandong University, China

    5 publications · 133 citations

    5

    h-index

  4. CP
    Christophe Pannecouque

    Rega Institute for Medical Research, Belgium

    5 publications · 133 citations

    5

    h-index

  5. UT
    Uwe T. Bornscheuer

    Universität Greifswald, Germany

    4 publications · 131 citations

    4

    h-index

1–5 of 823

Institutions

250

  1. Rega Institute for Medical Research

    Leuven, Belgium

    6 h-index

    19 publications

    432 citations

  2. Chinese Academy of Sciences

    Beijing, China

    6 h-index

    29 publications

    1.5K citations

  3. KU Leuven

    Leuven, Belgium

    6 h-index

    19 publications

    432 citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    5 h-index

    13 publications

    1.8K citations

  5. Shandong University

    Jinan, China

    5 h-index

    31 publications

    762 citations

  6. Philipps University of Marburg

    Marburg, Germany

    5 h-index

    15 publications

    647 citations

  7. Tianjin Institute of Industrial Biotechnology

    Tianjin, China

    4 h-index

    22 publications

    1.4K citations

  8. Universität Greifswald

    Greifswald, Germany

    4 h-index

    16 publications

    631 citations

1–8 of 250

Venues

  1. Journal of Medicinal Chemistry

    12 publications · 421 citations

    12

    h-index

  2. ACS Catalysis

    7 publications · 384 citations

    7

    h-index

  3. Journal of the American Chemical Society

    JACS · 6 publications · 348 citations

    6

    h-index

  4. Angewandte Chemie International Edition

    5 publications · 174 citations

    5

    h-index

  5. European Journal of Medicinal Chemistry

    5 publications · 130 citations

    5

    h-index

1–5