Designing aptamers which respond to intracellular oxidative stress and inhibit aggregation of mutant huntingtin

Analyzing real-time PCR data by the comparative CT method

Thomas D. Schmittgen, Kenneth J. Livak · Nature Protocols · 2008 · 26K citations

Computed Tomography, Image Analysis, Engineering +8

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

Marcy E. MacDonald · Cell · 1993 · 8.3K citations · Full text

Genome Instability, Novel Gene, Genetic Disorder +10

Improved method for high efficiency transformation of intact yeast cells

Daniel Gietz, Andrew St. Jean, Robin A. Woods et al. · Nucleic Acids Research · 1992 · 3.3K citations · Full text

Engineering, Medicine, Biotechnology +7

Sustained Therapeutic Reversal of Huntington's Disease by Transient Repression of Huntingtin Synthesis

Holly Kordasiewicz, Lisa M. Stanek, Edward V. Wancewicz et al. · Neuron · 2012 · 758 citations · Full text

Knockout Mouse, Molecular Biology, Degenerative Disease +7

Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

Russell G. Snell, John MacMillan, Jeremy P. Cheadle et al. · Nature Genetics · 1993 · 713 citations

Genetic Analysis, Phenotypic Variation, Genetic Disorder +8