Synthesis and biological evaluation of histone deacetylase and DNA topoisomerase II-Targeted inhibitors

FDA Approval Summary: Vorinostat for Treatment of Advanced Primary Cutaneous T-Cell Lymphoma

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Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

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A synthetic inhibitor of histone deacetylase, MS-27-275, with marked <i>in vivo</i> antitumor activity against human tumors

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Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.

Lisa M. Butler, David B. Agus, Howard I. Scher et al. · PubMed · 2000 · 617 citations

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Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA.

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