Concepedia

Topoisomerase Ii Function

Topoisomerase II Function is a molecular biological mechanism that belongs to the class of enzyme-mediated DNA regulatory processes, specifically distinguished by its role in catalyzing the transient double-strand breakage and rejoining of DNA to resolve topological entanglements during chromosome segregation, thereby enabling sister chromatid separation in eukaryotic cell division.

2.8K

Publications

166.9K

Citations

10.5K

Authors

2.1K

Institutions

Publications per year

2017–2026

320

Parents

Publications

2.8K

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

Scott H. Kaufmann, Serge Desnoyers, Yvonne Ottaviano et al. · PubMed · 1993 · 1.9K citations

, , +14

Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II

K M Tewey, Thomas C. Rowe, Liu Yang et al. · Science · 1984 · 1.5K citations

, , +17

An atypical topoisomerase II from archaea with implications for meiotic recombination

Agnès Bergerat, Bernard de Massy, Danielle Gadelle et al. · Nature · 1997 · 943 citations

, , +14

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

Peter N. Cockerill, William T. Garrard · Cell · 1986 · 901 citations

, , +10

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

K M Tewey, G L Chen, Eric M. Nelson et al. · Journal of Biological Chemistry · 1984 · 888 citations · Full text

, , +14

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Authors

10.5K

  1. NO
    Neil Osheroff

    Vanderbilt University, United States

    116 publications · 7.9K citations

    56

    h-index

  2. P
    Yves Pommier

    National Cancer Institute, United States

    60 publications · 4.7K citations

    38

    h-index

  3. LF
    Leroy F. Liu

    Rutgers, The State University of New Jersey, United States

    40 publications · 9.3K citations

    36

    h-index

  4. CA
    Caroline A. Austin

    Newcastle University, United Kingdom

    52 publications · 3.5K citations

    34

    h-index

  5. JL
    John L. Nitiss

    St. Jude Children's Research Hospital, United States

    39 publications · 1.8K citations

    25

    h-index

1–5 of 10.5K

Institutions

2.1K

  1. Vanderbilt University

    Nashville, United States

    57 h-index

    341 publications

    21.7K citations

  2. Harvard University

    Cambridge, United States

    48 h-index

    176 publications

    23K citations

  3. Johns Hopkins University

    Baltimore, United States

    42 h-index

    192 publications

    36.4K citations

  4. National Institutes of Health

    Bethesda, United States

    38 h-index

    217 publications

    17.5K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    37 h-index

    332 publications

    19.9K citations

  6. National Cancer Institute

    Bethesda, United States

    34 h-index

    154 publications

    9.1K citations

  7. Newcastle University

    Newcastle upon Tyne, United Kingdom

    31 h-index

    165 publications

    10.9K citations

  8. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    31 h-index

    160 publications

    11K citations

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Venues

  1. PubMed

    Repository · 282 publications · 19.9K citations

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  2. Journal of Biological Chemistry

    JBC · 163 publications · 12.7K citations

    62

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  3. Proceedings of the National Academy of Sciences

    PNAS · 78 publications · 9.6K citations

    54

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  4. Biochemistry

    96 publications · 6.6K citations

    51

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  5. Nucleic Acids Research

    105 publications · 5.4K citations

    41

    h-index

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