John L. Nitiss

DNA topoisomerase-targeting antitumor drugs can be studied in yeast.

John L. Nitiss, J C Wang · Proceedings of the National Academy of Sciences · 1988 · 496 citations · Full text

Drug Targeting, Nonessential Enzyme, Medicine +14

Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage

Karin C. Nitiss, Mobeen Malik, Xiaoping He et al. · Proceedings of the National Academy of Sciences · 2006 · 156 citations · Full text

Chromatin, Genome Instability, Tdp1 Gene +15

Mechanisms of cell killing by drugs that trap covalent complexes between DNA topoisomerases and DNA.

John L. Nitiss, James C. Wang · Molecular Pharmacology · 1996 · 145 citations

Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes

Sachin Katyal, Youngsoo Lee, Karin C. Nitiss et al. · Nature Neuroscience · 2014 · 145 citations · Full text

Chromatin, Genome Instability, Neurodegenerative Diseases +10

A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation

Yilun Sun, Lisa M. Jenkins, Yijun Su et al. · Science Advances · 2020 · 133 citations · Full text

Reductive Stress, Chromatin, Genome Instability +15