A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

Martin Jínek, Krzysztof Chylinski, Ines Fonfara, +3

Science

Crispr RnasAdaptive Bacterial ImmunityCrispr-associated Protein Cas9MedicineGenetics +13

Multiplex Genome Engineering Using CRISPR/Cas Systems

Le Cong, F. Ann Ran, David Cox, +8

Science

Single Crispr ArrayEngineeringShort RnasGeneticsSynthetic Biology +10

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

Alexis C. Komor, Y. Bill Kim, Michael S. Packer, +2

Nature

EngineeringGeneticsSynthetic BiologyMolecular BiologyDna Replication +9

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

Xiaojun Lian, Jianhua Zhang, Samira M. Azarin, +6

Nature Protocols

Directed Cardiomyocyte DifferentiationCardiomyopathyDevelopmental BiologyInduced Pluripotent Stem CellMedicine +4

CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering

Prashant Mali, John Aach, P. Benjamin Stranges, +5

Nature Biotechnology

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Fyodor D. Urnov, Jeffrey C. Miller, Ya-Li Lee, +7

Nature

GeneticsGenetic EngineeringMolecular BiologyZinc-finger NucleasesMolecular Genetics +4

Human CtIP promotes DNA end resection

Alessandro A. Sartori, Claudia Lukas, Julia Coates, +6

Nature

ChromatinGenome InstabilityHuman CtipDna ReplicationMedicine +2

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

Yannick Doyon, Jasmine M. McCammon, Jeffrey C. Miller, +10

Nature Biotechnology

Genome SurgeryNatural SciencesGeneticsGenetic EngineeringMolecular Biology +5

Expression of a site-specific endonuclease stimulates homologous recombination in mammalian cells.

Philippe Rouet, Fatima Smih, Maria Jasin

Proceedings of the National Academy of Sciences

GeneticsModified FormMolecular BiologyMolecular GeneticsDouble-strand Breaks +17

DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks

Megan van Overbeek, Daniel Capurso, Matthew M. Carter, +11

Molecular Cell

Genome InstabilityDna DamageDna AnalysisMolecular BiologyCas9-mediated Breaks +2