Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Heather R. Christofk, Matthew G. Vander Heiden, Marian H. Harris et al. · Nature · 2008 · 2.8K citations

Tumor Biology, Medicine, Molecular Biology +9

Targeting metastasis-initiating cells through the fatty acid receptor CD36

Gloria Pascual, Alexandra Avgustinova, Stefania Mejetta et al. · Nature · 2016 · 1.4K citations

Medicine, Metastasis-initiating Cells, Cancer Biology +4

Oxidative stress inhibits distant metastasis by human melanoma cells

Elena Piskounova, Michalis Agathocleous, Malea M. Murphy et al. · Nature · 2015 · 1.2K citations

Melanoma, Human Melanoma Cells, Medicine +3

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Dimitrios Anastasiou, George Poulogiannis, John M. Asara et al. · Science · 2011 · 1.2K citations · Full text

Lipid Peroxidation, Cell Death, Metabolic Remodeling +19

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

Sang‐Min Jeon, Navdeep S. Chandel, Nissim Hay · Nature · 2012 · 1.1K citations · Full text

Tumour Cell Survival, Reductive Stress, Signal Transduction +13