Concepedia

Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease

Motoki Fujimaki, Shinji Saiki, Yuanzhe Li, Naoko Kaga, Hikari Taka, Taku Hatano, Kei‐ichi Ishikawa, Yutaka Oji, Akio Mori, Ayami Okuzumi,

Neurology · 2018 · 103 citations · 31 references

Open access

Abstract

This study provides Class III evidence that decreased serum levels of caffeine and its metabolites identify patients with PD.

References

31

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

P. Naresh Kumar, Steven Henikoff, Pauline C. Ng · Nature Protocols · 2009 · 6.6K citations

Protein Function, Functional Genomics, Non-synonymous Variants +13

Gut microbiota are related to Parkinson's disease and clinical phenotype

Filip Scheperjans, Velma T. E. Aho, Pedro A. B. Pereira et al. · Movement Disorders · 2014 · 1.9K citations · Full text

Dysbiosis, Host-microbe Interactions, Gastroenterology +16

Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation.

Karimollah Hajian‐Tilaki · PubMed · 2013 · 1.8K citations · Full text

Curve Analysis, Disease Diagnosis, Roc Curve +15

Colonic bacterial composition in Parkinson's disease

Ali Keshavarzian, Stefan J. Green, Phillip A. Engen et al. · Movement Disorders · 2015 · 1.3K citations

Prospective study of caffeine consumption and risk of Parkinson's disease in men and women

Alberto Ascherio, Shumin M. Zhang, Miguel A. Hernán et al. · Annals of Neurology · 2001 · 677 citations