Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers

Clifford R. Jack, David S. Knopman, William J. Jagust et al. · The Lancet Neurology · 2013 · 4.4K citations

Life Sciences, Neurology, Neuroscience +16

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Michael T. Heneka, Markus P. Kummer, Andrea Stutz et al. · Nature · 2012 · 2.9K citations · Full text

Life Sciences, Neurology, Neuroscience +14

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

Life Sciences, Neurobiology, Neuroscience +16

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Eran Elinav, Till Strowig, Andrew L. Kau et al. · Cell · 2011 · 2K citations · Full text

Life Sciences, Immunology, Microbiology +10

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

Bin Zhang, Chris Gaiteri, Liviu‐Gabriel Bodea et al. · Cell · 2013 · 1.8K citations · Full text

Life Sciences, Bioinformatics, Genetics +14