Concepedia

Amyloid Seeding

Amyloid Seeding is a biochemical process in which preformed amyloid aggregates act as templates to accelerate the nucleation and fibril formation of soluble protein monomers, distinguishing it from de novo amyloidogenesis by its dependence on existing aggregate structures.

364

Publications

36.2K

Citations

1.9K

Authors

600

Institutions

Publications per year

2017–2026

140

Parents

Publications

364

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

Joseph T. Jarrett, Elizabeth P. Berger, Peter T. Lansbury · Biochemistry · 1993 · 2K citations

, , +17

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

Carmen Venegas, Sathish Kumar, Bernardo S. Franklin et al. · Nature · 2017 · 984 citations

, , +16

Exogenous Induction of Cerebral ß-Amyloidogenesis Is Governed by Agent and Host

Melanie Meyer‐Luehmann, Janaky Coomaraswamy, Tristan Bolmont et al. · Science · 2006 · 953 citations · Full text

, , +17

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

Laura A. Volpicelli‐Daley, Kelvin C. Luk, Virginia M.‐Y. Lee · Nature Protocols · 2014 · 772 citations

, , +17

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

William A. Eimer, Deepak Kumar Vijaya Kumar, Nanda Kumar N. Shanmugam et al. · Neuron · 2018 · 675 citations · Full text

, , +14

1–5 of 364

Authors

1.9K

  1. MJ
    Mathias Jucker

    Hertie Institute for Clinical Brain Research, Germany

    13 publications · 2.1K citations

    13

    h-index

  2. JZ
    Jie Zheng

    University of Akron, United States

    11 publications · 265 citations

    11

    h-index

  3. DE
    David Eisenberg

    University of California, Los Angeles, United States

    10 publications · 1.6K citations

    10

    h-index

  4. HN
    Hironobu Naiki

    University of Fukui, Japan

    9 publications · 1.1K citations

    9

    h-index

  5. MS
    Matthias Staufenbiel

    Novartis (Switzerland), Switzerland

    9 publications · 1.7K citations

    9

    h-index

1–5 of 1.9K

Institutions

600

  1. German Center for Neurodegenerative Diseases

    Bonn, Germany

    21 h-index

    124 publications

    18.9K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    86 publications

    4.8K citations

  3. University of Tübingen

    Tübingen, Germany

    13 h-index

    83 publications

    22.3K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    13 h-index

    69 publications

    7.6K citations

  5. Hertie Institute for Clinical Brain Research

    Tübingen, Germany

    12 h-index

    95 publications

    23.1K citations

  6. National Institutes of Health

    Bethesda, United States

    11 h-index

    29 publications

    2.1K citations

  7. University of Akron

    Akron, United States

    11 h-index

    60 publications

    1.5K citations

  8. University of Fukui

    Fukui-shi, Japan

    10 h-index

    12 publications

    1.5K citations

1–8 of 600

Venues

  1. Journal of Biological Chemistry

    JBC · 28 publications · 2.5K citations

    24

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 23 publications · 4.3K citations

    22

    h-index

  3. Biochemistry

    19 publications · 3.6K citations

    17

    h-index

  4. PLoS ONE

    16 publications · 616 citations

    15

    h-index

  5. Scientific Reports

    14 publications · 668 citations

    14

    h-index

1–5