Concepedia

JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component

Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei,

Molecular Cancer · 2017 · 92 citations · 34 references

DOIFull text

Open access

Abstract

Our results indicate that JMJD6 is critically involved in melanoma carcinogenesis, supporting the pursuit of JMJD6 as a potential biomarker for melanoma aggressiveness and a target for melanoma intervention.

References

34

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data

Ethan Cerami, Jianjiong Gao, Uğur Doğrusöz et al. · Cancer Discovery · 2012 · 17.9K citations · Full text

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.6K citations · Full text

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A receptor for phosphatidylserine-specific clearance of apoptotic cells

Valerie A. Fadok, Donna L. Bratton, David M. Rose et al. · Nature · 2000 · 1.5K citations

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HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

Charles J. David, Mo Chen, Marcela C. Assanah et al. · Nature · 2009 · 1.2K citations · Full text

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JMJD6 Is a Histone Arginine Demethylase

Bingsheng Chang, Yue Chen, Yingming Zhao et al. · Science · 2007 · 717 citations

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