SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability

Lei Li, Lan Shi, Shangda Yang, +12

Nature Communications

Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis

Shumeng Liu, Huajing Yu, Yongqing Liu, +18

Molecular Cell

SpermatogenesisChromatinHistone CrotonylationDevelopmental BiologyChromatin Structure +7

Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis

Wenzhe Si, Wei Huang, Yu Zheng, +17

Cancer Cell

Breast Cancer MetastasisBreast OncologyMedicineReciprocal Feedback LoopCancer Biology +6

Global crotonylome reveals CDYL-regulated RPA1 crotonylation in homologous recombination–mediated DNA repair

Huajing Yu, Chen Bu, Yuncheng Liu, +15

Science Advances

JMJD6 Promotes Colon Carcinogenesis through Negative Regulation of p53 by Hydroxylation

Feng Wang, Lin He, Peiwei Huangyang, +13

PLoS Biology

JMJD6 promotes melanoma carcinogenesis through regulation of the alternative splicing of PAK1, a key MAPK signaling component

Xujun Liu, Wenzhe Si, Xinhua Liu, +9

Molecular Cancer

Imbalance of the reciprocally inhibitory loop between the ubiquitin-specific protease USP43 and EGFR/PI3K/AKT drives breast carcinogenesis

Lin He, Xinhua Liu, Jianguo Yang, +17

Cell Research

Ubiquitin-specific Protease Usp43Tumor BiologySystems BiologyBreast OncologyMedicine +8

The existence of a nonclassical TCA cycle in the nucleus that wires the metabolic-epigenetic circuitry

Xujun Liu, Wenzhe Si, Lin He, +20

Signal Transduction and Targeted Therapy

Association of AKT1 Gene Polymorphisms With Risk of Schizophrenia and With Response to Antipsychotics in the Chinese Population

M Q Xu, Qing-He Xing, Yonglan Zheng, +7

The Journal of Clinical Psychiatry

Nucleation of DNA repair factors by FOXA1 links DNA demethylation to transcriptional pioneering

Yu Zhang, Di Zhang, Qian Li, +13

Nature Genetics

ChromatinGenome InstabilityTranscriptional RegulationChromatin RemodelingNatural Sciences +8