Concepedia

Caspase-1 Is an Apical Caspase Leading to Caspase-3 Cleavage in the AIM2 Inflammasome Response, Independent of Caspase-8

Vitaliya Sagulenko, Nazarii Vitak, Parimala R. Vajjhala, James E. Vince, Katryn J. Stacey

Journal of Molecular Biology · 2017 · 86 citations · 49 references

DOI

Concepts

References

49

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations

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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki, Irma B. Stowe, Bettina L. Lee et al. · Nature · 2015 · 3.7K citations

, , +13

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi et al. · Nature · 2017 · 3.2K citations

, , +13

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Franz Bauernfeind, Gábor Horváth, Andrea Stutz et al. · The Journal of Immunology · 2009 · 2.9K citations · Full text

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Non-canonical inflammasome activation targets caspase-11

Nobuhiko Kayagaki, Søren Warming, Mohamed Lamkanfi et al. · Nature · 2011 · 2.5K citations

, , +12