Concepedia

Aim2 Inflammasome

The AIM2 Inflammasome is an intracellular multiprotein complex belonging to the innate immune sensor family that specifically recognizes cytosolic double-stranded DNA and induces caspase-1-dependent inflammation and pyroptosis through the assembly of an oligomeric signaling platform mediated by the AIM2 protein.

353

Publications

37.7K

Citations

2.4K

Authors

701

Institutions

Publications per year

2017–2026

220

Variants

Absent In Melanoma 2 Inflammasome

Parents

Publications

353

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis et al. · Nature · 2009 · 2.6K citations · Full text

, , +11

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Teresa Fernandes‐Alnemri, Je‐Wook Yu, Pinaki Datta et al. · Nature · 2009 · 1.8K citations · Full text

, , +12

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Vijay Rathinam, Zhaozhao Jiang, Stephen N. Waggoner et al. · Nature Immunology · 2010 · 1.3K citations · Full text

, , +16

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux

Yuan He, Melody Yue Zeng, Dahai Yang et al. · Nature · 2016 · 1.3K citations

, , +17

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Tilmann Bürckstümmer, Christoph Baumann, Stephan Blüml et al. · Nature Immunology · 2009 · 1.1K citations

, , +12

1–5 of 353

Authors

2.4K

  1. KA
    Katherine A. Fitzgerald

    University of Massachusetts Chan Medical School, United States

    12 publications · 5.8K citations

    12

    h-index

  2. VH
    Veit Hornung

    Ludwig-Maximilians-Universität München, Germany

    11 publications · 5.6K citations

    11

    h-index

  3. TK
    Thirumala‐Devi Kanneganti

    St. Jude Children's Research Hospital, United States

    11 publications · 2.3K citations

    11

    h-index

  4. DC
    Divaker Choubey

    University of Cincinnati, United States

    8 publications · 615 citations

    8

    h-index

  5. TH
    Thomas Henry

    Inserm, France

    8 publications · 1.4K citations

    8

    h-index

1–5 of 2.4K

Institutions

701

  1. University of Massachusetts Chan Medical School

    Worcester, United States

    14 h-index

    53 publications

    30.6K citations

  2. St. Jude Children's Research Hospital

    Memphis, United States

    11 h-index

    50 publications

    13.9K citations

  3. Ludwig-Maximilians-Universität München

    Munich, Germany

    10 h-index

    78 publications

    11.6K citations

  4. Inserm

    Paris, France

    9 h-index

    64 publications

    5.6K citations

  5. University of Bonn

    Bonn, Germany

    9 h-index

    27 publications

    7.1K citations

  6. University Hospital Bonn

    Bonn, Germany

    9 h-index

    28 publications

    11.5K citations

  7. Chinese Academy of Sciences

    Beijing, China

    9 h-index

    34 publications

    4.2K citations

  8. China Pharmaceutical University

    Nanjing, China

    8 h-index

    39 publications

    3.9K citations

1–8 of 701

Venues

  1. The Journal of Immunology

    JI · 27 publications · 2K citations

    23

    h-index

  2. Scientific Reports

    10 publications · 575 citations

    10

    h-index

  3. Nature Communications

    9 publications · 1.9K citations

    9

    h-index

  4. Frontiers in Immunology

    7 publications · 396 citations

    8

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 1.1K citations

    8

    h-index

1–5