Concepedia

CRISPR knock out CTLA-4 enhances the anti-tumor activity of cytotoxic T lymphocytes

Long Shi, Tongyu Meng, Zhilong Zhao, Jinsheng Han, Wei Zhang, Fei Gao, Jianhui Cai

Gene · 2017 · 65 citations · 33 references

DOI

Concepts

References

33

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Gordon J. Freeman, Andrew J. Long, Yoshiko Iwai et al. · The Journal of Experimental Medicine · 2000 · 5.2K citations · Full text

, , +17

Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

Yasumasa Ishida, Yasutoshi Agata, Kei‐ichi Shibahara et al. · The EMBO Journal · 1992 · 3.2K citations · Full text

, , +12

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

Matthew F. Krummel, James P. Allison · The Journal of Experimental Medicine · 1995 · 2.2K citations · Full text

, , +17

CTLA-4 can function as a negative regulator of T cell activation

Theresa L. Walunas, Deborah J. Lenschow, Christina Y. Bakker et al. · Immunity · 1994 · 2.2K citations

, , +14

A Cell Culture Model for T Lymphocyte Clonal Anergy

Ronald H. Schwartz · Science · 1990 · 1.9K citations

, , +17