Concepedia

Sirtuin 3 Deficiency Accelerates Hypertensive Cardiac Remodeling by Impairing Angiogenesis

Tong Wei, Gaojian Huang, Jing Gao, Chenglin Huang, Mengwei Sun, Jian Wu, Juan Bu, Weili Shen

Journal of the American Heart Association · 2017 · 131 citations · 34 references

DOIFull text

Open access

Abstract

Collectively, these findings suggest that SIRT3 could promote angiogenesis through attenuating mitochondrial dysfunction caused by defective mitophagy.

References

34

Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation

David B. Lombard, Frederick W. Alt, Hwei-Ling Cheng et al. · Molecular and Cellular Biology · 2007 · 1.2K citations · Full text

, , +10

Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

Nagalingam R. Sundaresan, Madhu Gupta, Gene Kim et al. · Journal of Clinical Investigation · 2009 · 982 citations · Full text

Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure

Ichiro Shiojima · Journal of Clinical Investigation · 2005 · 925 citations · Full text

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

Angela Hafner, Jing Dai, Ana P. Gomes et al. · Aging · 2010 · 533 citations · Full text

, , +18

Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice

Guohua Gong, Moshi Song, György Csordás et al. · Science · 2015 · 438 citations · Full text